Science

Academic research

Academic
research

Building verifiable standards for science-based beauty through extracellular vesicle research

AESOMED focuses on extracellular vesicle-based science beauty, with research centered on HREV®, AesoBoost® recombinant technology, and FORMULA 313.

We believe science-based beauty should move beyond concept-driven language. It should be supported by verifiable particle characterization, mechanism studies, third-party testing, and peer-reviewed publication.

Biomaterials Research paper cover

Featured Publication

Intradermal Delivery of Catalase via Extracellular Vesicles for Targeted Photoaging Therapy

Biomaterials Research, 2026;30:Article 0329
DOI: 10.34133/bmr.0329

This study investigated catalase-loaded extracellular vesicles as a targeted delivery approach for photoaging-related oxidative stress. The research established a 313 cell line capable of producing CAT-loaded EVs and evaluated vesicle integrity, enzymatic activity, cellular uptake, oxidative stress, inflammatory response, collagen preservation, and in vivo photoaging models.

In experimental models, 313EVs were observed to reduce UVB-associated oxidative stress, support collagen preservation, and show effects related to inflammation regulation and improvement of photoaging-associated skin structure.

Research Focus

Extracellular Vesicle Delivery Platform

Exploring extracellular vesicles as naturally derived nanoscale carriers for proteins, nucleic acids, and cell-signaling molecules.

Photoaging and Oxidative Stress

Studying UVB-induced ROS, DNA damage, inflammatory signaling, collagen degradation, and related mechanisms of skin photoaging.

HREV® and FORMULA 313

Building a scientific evidence chain for HREV® through particle characterization, bioactive-factor research, stability evaluation, verifiable concentration, and cosmetic compliance.

Research Collaborators

  • School of Life Sciences, Jilin University
  • Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine
  • Department of Dermatology, Second Affiliated Hospital of Naval Medical University
  • Department of Chemistry, University of Bergen
  • Aesomed Bioscience Hong Kong Limited

Public Indexing

This page introduces AESOMED-related scientific research and the research foundation behind science-based beauty. FORMULA 313 is a cosmetic-related product, not a drug. Findings from cell, tissue, or animal models do not equal human clinical efficacy and should not be interpreted as diagnosis, treatment, or medical advice.